What is Anti-double stranded DNA antibodies?

Anti-double stranded DNA (Anti-dsDNA) antibodies are a group of anti-nuclear antibodies (ANA) the target antigen of which is double stranded DNA. Blood tests such as enzyme-linked immunosorbent assay (ELISA) and immunofluorescence are routinely performed to detect anti-dsDNA antibodies in diagnostic laboratories.

What does a positive double stranded DNA antibody test mean?

A positive result for double-stranded DNA (dsDNA) IgG antibodies in the appropriate clinical context is suggestive of systemic lupus erythematosus (SLE).

What diseases cause double stranded DNA?

Double Stranded DNA Antibody

  • Antigen.
  • Antibody.
  • Peptide.
  • Double Stranded DNA.
  • Antinuclear Antibody.
  • Systemic Lupus Erythematosus.
  • Lupus Erythematosus Nephritis.
  • Lupus Vulgaris.

What does double stranded DNA indicate?

Introduction. Elevated anti-double-stranded (ds) DNA antibody titers are diagnostic and prognostic markers of systemic lupus erythematosus (SLE), and their presence is well documented to correlate with lupus nephritis.

Do healthy people have dsDNA antibodies?

Antibodies to native double-stranded DNA are present in the blood of healthy people, but their level is increased manifold in patients with autoimmune diseases, when the human immune system becomes hyperactive and attacks normal, healthy tissues.

What diseases can cause a positive ANA?

Conditions that usually cause a positive ANA test include:

  • Systemic lupus erythematosus.
  • Sjögren’s syndrome — a disease that causes dry eyes and mouth.
  • Scleroderma — a connective tissue disease.
  • Rheumatoid arthritis — this causes joint damage, pain, and swelling.
  • Polymyositis — a disease that causes muscle weakness.

Does everyone have Anti-dsDNA antibodies?

Anti-dsDNA Antibody Less than 1% of healthy individuals have this antibody, making it helpful in confirming a diagnosis of systemic lupus.

Does anti-dsDNA mean lupus?

The anti-double stranded DNA (anti-dsDNA) test is used to help diagnose lupus in a person who has a positive result on a test for antinuclear antibody (ANA) and has clinical signs and symptoms that suggest lupus. Typically, an ANA test is the first test performed to evaluate an individual for an autoimmune disorder.

What is the normal range DNA ds antibody?

pH—to determine if the urine is acidic (normal) or alkaline (suggests infection or problems in the way the kidney functions).

  • Protein—the level should be 0 or trace.
  • Protein/creatinine ratio—this is an add-on test to quantify the protein if the above is abnormal

    • What does high anti-DNA(ds) level indicate?

    A high level of anti-dsDNA in the blood is strongly associated with lupus and is often significantly increased during or just prior to a flare-up. When the anti-dsDNA is positive and the person tested has other clinical signs and symptoms associated with lupus, it means that the person tested likely has lupus.

    What is anti dsDNA antibodies?

    Muscle pain

  • Arthritis-like pain in one or more joints (but no or little joint damage)
  • Red rash that frequently resembles a butterfly across the nose and cheek areas (malar rash)
  • Low-grade fever
  • Persistent fatigue,weakness
  • Skin sensitivity to light
  • Hair and weight loss
  • Numbness or tingling in the hands or feet

    • Do both strands of DNA contain genes?

    The two strands in DNA are similar, but different in their makeup. Both strands have the same kind of genes, but the actual genes on each strand can be different, for example, the genes for hair colour are at the same position on a strand of DNA, but the gene on Strand 1 is for brown hair, and the gene on Strand 2 might be for red hair.