What are the absolute contraindications of streptokinase?

Because thrombolytic therapy increases the risk of bleeding, Streptase, Streptokinase, is contraindicated in the following situations:

  • active internal bleeding.
  • recent (within 2 months) cerebrovascular accident, intracranial or intraspinal surgery (see WARNINGS)
  • intracranial neoplasm.
  • severe uncontrolled hypertension.

Why streptokinase is not used?

Although much less expensive, this makes Streptokinase a less attractive agent for acute treatments in ischemic stroke than tPA products. Studies of streptokinase in acute stroke were stopped due to an increase in mortality compared to placebo due to increased haemorrhage rates.

What is the difference between tPA and streptokinase?

These trials show that tPA achieves better lysis rates than streptokinase, but the theoretic advantage of fibrin specificity does not result in fewer adverse effects or greater preservation of LV function.

What is the most important complication of streptokinase therapy?

The hemorrhagic stroke as the most serious ADR of streptokinase was documented in three patients.

What is a contraindication for thrombolytic therapy?

Relative contraindications (not absolute) to fibrinolytic therapy include: Uncontrolled hypertension (BP > 180/110), either currently or in the past. Intracranial abnormality not listed as absolute contraindication (i.e. benign intracranial tumor) Ischemic stroke more than 3 months prior.

What are the negative effects of streptokinase?

The most common ADRs were chest pain, hypotension, coughing, and ecchymosis with the frequency of more than fifty percent. The hemorrhagic stroke as the most serious ADR of streptokinase was documented in three patients.

What are the contraindications to thrombolytic therapy?

Absolute Contraindications for Thrombolytic Treatment

  • Recent intracranial hemorrhage (ICH)
  • Structural cerebral vascular lesion.
  • Intracranial neoplasm.
  • Ischemic stroke within three months.
  • Possible aortic dissection.
  • Active bleeding or bleeding diathesis (excluding menses)

Why streptokinase is called clot buster?

Streptokinase is an enzyme. It is also called as fibrinolysis. The name is given because it helps in breaking down the fibrin, the main component of blood clots. Hence, it is known as a clot buster.

What is the difference between streptokinase and alteplase?

Alteplase is a pharmacologic tPA and functions in the same way. Streptokinase: Streptococci produce this substance. When given as a drug, streptokinase works with the body’s own supply of plasminogen. Plasminogen, in the presence of streptokinase, will become plasmin at a fast rate.

What is the mechanism of action of streptokinase?

Streptokinase creates an active complex which promotes the cleavage of the Arg/Val bond in plasminogen to form the proteolytic enzyme plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.

What is urokinase used for?

Urokinase injection is used to dissolve blood clots that have formed in the lungs (pulmonary embolism). This medicine was available only with your doctor’s prescription.