Why is mesna given ifosfamide?

USES: This medication is used to reduce the risk of bleeding in the bladder (hemorrhagic cystitis), which is a very serious side effect of treatment with a cancer chemotherapy drug called ifosfamide. Mesna helps to protect the lining of the bladder against damage from ifosfamide.

What chemo do you give mesna with?

Mesna helps protect your bladder to prevent irritation and bleeding. Mesna is always given with ifosfamide. Most people who have treatment with cyclophosphamide are not given doses high enough to cause bleeding from the bladder.

Why mesna is given simultaneously with cyclophosphamide?

Mesna is converted in the blood to a biochemically inactive compound that is reduced back to mesna in the kidneys. In this way it has the potential to protect the bladder mucosa without interfering with the antineoplastic effect of cyclophosphamide.

Which drug is given together with ifosfamide?

The medication mesna (see mesna) may be given with or following treatment with ifosfamide to prevent or decrease the severity of this side effect.

Can ifosfamide and mesna be given together?

The final 12-hour infusion of mesna, after long-term or 24 hour infusion of ifosfamide, may be replaced by boluses at 28, 32 and 36 hours, each of 20% (w/w) of the ifosfamide dose, or by oral mesna. Mesna can be mixed in the same infusion bag as the ifosfamide.

What is ifosfamide used for?

Ifosfamide is used in combination with other medications to treat cancer of the testicles that has not improved or that has worsened after treatment with other medications or radiation therapy. Ifosfamide is in a class of medications called alkylating agents.

When is mesna given ifosfamide?

Then each 24 hour infusion of ifosfamide is given with a concurrent 24 hour infusion (100% w/w) of mesna. A 12 hour infusion of mesna (60% (w/w) of the final 24 hour dose of ifosfamide) should be commenced as the ifosfamide-mesna infusion finishes.

Can mesna be mixed with ifosfamide?

Mesna can be mixed in the same infusion bag as the ifosfamide.

What is the purpose of mesna?

Mesna is used to reduce the risk of hemorrhagic cystitis (a condition that causes inflammation of the bladder and can result in serious bleeding) in people who receive ifosfamide (a medication used for the treatment of cancer). Mesna is in a class of medications called cytoprotectants.

Does ifosfamide cause nephrotoxicity?

Nephrotoxicity due to direct tubular injury is a prominent complication of ifosfamide therapy; glomerular toxicity may also occur.

When do you use mesna?

Mesna is used to reduce the risk of hemorrhagic cystitis (a condition that causes inflammation of the bladder and can result in serious bleeding) in people who receive ifosfamide (a medication used for the treatment of cancer).

What is mesna effect?

This medication is used to reduce the risk of bleeding in the bladder (hemorrhagic cystitis), which is a very serious side effect of treatment with a cancer chemotherapy drug called ifosfamide. Mesna helps to protect the lining of the bladder against damage from ifosfamide.