What is the Raskin protocol?

Raskin developed the original repetitive dose IV DHE protocol to treat refractory migraine in 1986. This became the foundation for inpatient and in-clinic treatments administered over a number of days. The original protocol called for IV DHE 0.3–1 mg every 8 hours with IV metoclopramide 10 mg for 2–3 days.

What is a DHE protocol?

Dihydroergotamine (DHE) infusion is a migraine treatment that works by therapeutically contracting some of the blood vessels that supply the tissues that cover and protect the brain. It also stops the release of natural substances in the brain that contribute to migraine pain.

Is dihydroergotamine good for migraines?

Forms of dihydroergotamine DHE is a good migraine treatment option because it comes in many different forms, including nasal sprays, injection and intravenous infusion (delivered directly into the vein).

How long does dihydroergotamine take to work?

You should feel some relief within 30 minutes of using this medication. The dosage is based on your medical condition and response to treatment. Ask your doctor how often you can use this medication to treat your migraine headaches.

How long does DHE infusion last?

You will carry on having infusions for the next three to four days – each about eight hours apart and lasting an hour, depending on the rate.

How do you give dihydroergotamine?

45® (dihydroergotamine mesylate) Injection, USP should be administered in a dose of 1 mL intravenously, intramuscularly or subcutaneously. The dose can be repeated, as needed, at 1 hour intervals to a total dose of 3 mL for intramuscular or subcutaneous delivery or 2 mL for intravenous delivery in a 24 hour period.

Where do you inject dihydroergotamine?

Dihydroergotamine comes as a solution to inject subcutaneously (under the skin), intramuscularly (in the muscle), or intravenouslyly (into a vein).

Why is Benadryl in a migraine cocktail?

Dehydration itself can also be a migraine trigger. In these cases, doctors may recommend IV fluids. Antiemetics: These drugs reduce symptoms such as nausea and vomiting. To reduce the risk of side effects, doctors may also include the antihistamine diphenhydramine (Benadryl).