What is the hypothesis of diabetes?
The Accelerator Hypothesis argues that people in whom type 1 diabetes develops are subject to the same weight increase, the same insulin resistance, the same metabolic upregulation, and the same acceleration in β-cell loss as those with type 2 diabetes.
How does diabetes cause diabetic cardiomyopathy?
In patients with type 1 diabetes mellitus, hyperglycemia-induced activation of systemic RAAS seems to play a role in the pathogenesis of diabetic cardiomyopathy. Experimental evidence also supports a role for increased mineralocorticoids in systemic and tissue insulin resistance.
Is cardiomyopathy related to diabetes?
Diabetic cardiomyopathy is defined as the presence of abnormal cardiac structure and performance in the absence of other cardiac risk factors, such coronary artery disease, hypertension, and significant valvular disease.
How is diabetic cardiomyopathy diagnosed?
Echocardiography. Nowadays, this non-invasive approach is the gold standard diagnostic tool to identify structural cardiac disorders. It provides a reliable identification of the structural abnormalities seen in early stages of DCM, such as impaired diastolic filling and left ventricle hypertrophy.
How common is diabetic cardiomyopathy?
Conclusion. Diabetic cardiomyopathy is relatively common in the community with a prevalence of 1.1%. The morbidity and mortality of patients with diabetic cardiomyopathy is high.
Can diabetes 1 cause cardiomyopathy?
Diabetic cardiomyopathy pathophysiology is widely studied in T2D, while its mechanisms in T1D are less clear. Hyperglycemia and chronic inflammation present in both types, promoting cardiac hypertrophy and fibrosis, increasing myocardial stiffness, and resulting in diastolic and systolic dysfunction.
How does diabetes affect cardiomyopathy?
Diabetes is also associated with its own set of complications that exacerbate the tendency to cardiomyopathy, including autonomic neuropathy, endothelial dysfunction, peripheral insulin resistance, hyperglycemia and abnormal cardiac fuel usage.
What is hypothesis purpose?
The Purpose of a Hypothesis A hypothesis is used in an experiment to define the relationship between two variables. The purpose of a hypothesis is to find the answer to a question. A formalized hypothesis will force us to think about what results we should look for in an experiment.
What is meant by hypothesis give an example?
Hypotheses are usually written as if/then statements, such as if someone eats a lot of sugar, then they will develop cavities in their teeth. These statements identify specific variables (in this case, eating a large amount of sugar) and propose a result (in this case, teeth developing cavities).
What does hypothesis mean in simple terms?
A hypothesis is an assumption, an idea that is proposed for the sake of argument so that it can be tested to see if it might be true. In the scientific method, the hypothesis is constructed before any applicable research has been done, apart from a basic background review.
What is the pathophysiology of diabetic cardiomyopathy?
The aetiology of diabetic cardiomyopathy is multifactorial. Despite decades of research aiming to determine the causes of this distinct pathology, more research is needed. Current hypotheses include insulin resistance, endothelial dysfunction, fibrosis, cardiac lipotoxicity and energetic impairment.
Is cardiomyopathy associated with Type 1 or Type 2 diabetes mellitus?
The phenotypes and underlying mechanisms of diabetic cardiomyopathy in type 2 diabetes mellitus have been mostly investigated in db/db mice, ob/ob mice, Zucker diabetic fatty rats, and diabetic patients. 13 The impact of type 1 diabetes mellitus on systolic and diastolic functions is less clear.
What is the evidence base for diabetic cardiomyopathy in T2D?
Excess adiposity and altered fat distribution have been shown to contribute to diabetic cardiomyopathy in T1D similar to T2D. For the purposes of this review, we will be focusing on the evidence base behind diabetic cardiomyopathy in T2D. MYOCARDIAL ENERGY METABOLISM Normal vs the diabetic heart
What triggers a diabetic cardiomyopathic phenotype?
The relationship between diabetic metabolic disturbances (triggers) and the mediators, effectors, and intracellular targets that lead to a diabetic cardiomyopathic phenotype. NEFAs play a critical role in triggering the development of cellular insulin resistance but also have been implicated in the development of myocardial contractile dysfunction.