What is the difference between doxorubicin and liposomal doxorubicin?

Liposomal doxorubicin is a chemotherapy drug that is also called by the brand names Caelyx or Myocet. It contains the chemotherapy drug doxorubicin (Adriamycin) wrapped up in a fatty covering called a liposome. It is a treatment for some types of cancer, including: breast cancer.

What is an important feature of doxorubicin HCL liposomal?

Liposomal doxorubicin is an anthracycline-type chemotherapy drug that is used to treat certain types of cancer (such as ovarian cancer, AIDS-related Kaposi’s sarcoma, multiple myeloma). It works by slowing or stopping cancer cell growth.

Is doxorubicin a liposome?

It is the drug doxorubicin encapsulated in a closed lipid sphere (liposome). This medication is classified as an “anthracycline antibiotic.” (For more detail, see “How this drug works” section below).

What is the process of encapsulating doxorubicin HCI in liposomes?

3 “Pegylation” is the process whereby the doxorubicin-containing liposomes are enclosed within a PEG layer. 2 Pegylation protects the liposomes from detection by the mononuclear phagocyte system2 and provides a stabilization effect that reduces adhesion to cells, blood vessel walls and other surfaces.

Why is liposomal doxorubicin less cardiotoxic?

The use of liposomal DOX formulations has reduced cardiotoxicity because of lower myocardial drug concentrations. Liposomes are designed to avoid direct contact of the cytotoxic agent with the vasculature, and influence biodistribution based on leakiness of the endothelium of various organs.

What is liposomal formulation?

A liposome drug formulation is different from (1) an emulsion, which is a dispersed system of oil in water, or water in oil phases containing one or more surfactants, (2) a microemulsion, which is a thermodynamically stable two phase system containing oil or lipid, water and surfactants, and (3) a drug-lipid complex.

Why doxorubicin is red?

Other serious side effects may include allergic reactions such as anaphylaxis, heart damage, tissue damage at the site of injection, radiation recall, and treatment-related leukemia. People often experience red discoloration of the urine for a few days….Doxorubicin.

Clinical data
ATC code L01DB01 (WHO)
Legal status

What is the meaning of liposomal?

(LY-poh-SOH-mul) A drug preparation that contains the active drug inside very tiny, fat-like particles. This form is easier for the body to absorb and allows more drug to get to the target area of the body, such as a tumor. Liposomal drugs may have fewer side effects and work better than other forms of the drug.

What is PEGylated liposomal doxorubicin?

Pegylated liposomal doxorubicin is a formulation of doxorubicin in which the molecule itself is packaged in a liposome made of various lipids with an outer coating of polyethylene glycol. Liposomal technology is being used in increasing amounts in the therapy of a variety of cancers, including ovarian cancers.

How effective is liposomal doxorubicin?

There were no randomized controlled trials. According to response evaluation criteria in solid tumors criteria, the response rates of doxorubicin-based regimens and liposomal doxorubicin were 44% (28.6–54) and 33.3% (0–75) on average, respectively.

Does liposomal doxorubicin cause hair loss?

v Hair loss is unusual with liposomal doxorubicin, but some patients do experience more hair loss than others. If hair loss occurs, hair growth should return upon completion of treatment. v Nausea and vomiting are not unusual but are less common today than in the past because of much improved anti-nausea medications.

What are the main components of a liposomes?

Phospholipids are the main component of liposomes, which are amphiphilic molecules with hydrophobic tail and hydrophilic head group. The head groups of phospholipids are hydrophilic, while their fatty acid tails are usually acyl chains and hydrophobic.