What is piperazine derivative?

Antihistamine piperazine derivatives are histamine H-1 receptor antagonists used to treat anxiety, chronic urticaria (skin rash associated with food allergy), pruritis (itching), and preoperative sedation.

Which is example of piperazine derivatives?

The piperazine derivatives include 1-benzylpiperazine (BZP), 1,3-trifluoromethylphenylpiperazine (TFMPP), 1-(3-chlorophenyl) piperazine (mCPP) and 1-(4-methoxyphenyl) piperazine (MeOPP); a full summary of their chemical properties is presented in the ‘Physical Descriptions’ section.

What is the use of piperazine?

Piperazine belongs to the family of medicines called anthelmintics. Anthelmintics are used in the treatment of worm infections. Piperazine is used to treat: common roundworms (ascariasis) and.

What is piperazine ring?

Piperazine (/paɪˈpɛrəziːn/) is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. Piperazine exists as small alkaline deliquescent crystals with a saline taste.

What is a piperazine ring?

How is piperazine made?

Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.

What is the mechanism of action of piperazine?

Mechanism of action Piperazine acts as a γ-aminobutyric acid (GABA) agonist, causing chloride channel opening, neural hyperpolarization and flaccid paralysis of susceptible parasites. Affected worms are then expelled from their predilection sites by normal enteric movements.

What is the function of piperazine?

Is piperazine a base?

It is a conjugate base of a piperazinium(2+). Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms.

What is piperazine made of?

What is the structure of piperazine?

C4H10N2Piperazine / Formula