What is bone marrow cytogenetics?

Cytogenetics involves testing samples of tissue, blood, or bone marrow in a laboratory to look for changes in chromosomes, including broken, missing, rearranged, or extra chromosomes. Changes in certain chromosomes may be a sign of a genetic disease or condition or some types of cancer.

What is a bone marrow clot section?

The clot section is used to evaluate bone marrow cellularity. The clot section is often optimal for immunohistochemical (IHC) staining as it has not been exposed to decalcification chemicals. Often, the blood clot is friable upon sectioning (after paraffin processing).

What is bone marrow morphology test?

Test Includes Includes histologic and cytologic preparation, staining and interpretation of bone marrow smears, biopsies, clot and peripheral blood smears for morphological evaluation, including gross and microscopic examination, decalcification procedure and special stains.

What does a bone marrow biopsy show?

Bone marrow aspiration and bone marrow biopsy can show whether your bone marrow is healthy and making normal amounts of blood cells. Doctors use these procedures to diagnose and monitor blood and marrow diseases, including some cancers, as well as fevers of unknown origin.

What is the purpose of cytogenetics?

The purpose of cytogenetics is to study the structure and normal and pathological functioning of chromosomes (condensation, recombination, repair, segregation, transmission) and chromatin (organization and role in the regulation of gene expression).

What if bone marrow biopsy is negative?

When these tests are negative, examining the marrow can reveal problems with the red blood cells that are uncommon causes of anemia (sideroblastic anemia, aplastic anemia).

What if the bone marrow test is positive?

Abnormal results may be due to cancer, infection, or another bone marrow disease. Your doctor may need to order more tests to confirm a diagnosis. And they will discuss the results and treatment options if needed and plan your next steps during the follow-up appointment.

What is the significance of bone marrow smear examination?

A bone marrow biopsy is usually done if your healthcare provider thinks that you have a problem making blood cells. A specialist called a pathologist examines blood and bone marrow samples in a lab. The pathologist can check your bone marrow for any of the following: Unexplained anemia (lack of red blood cells)

What if bone marrow test is positive?

What are the symptoms of bone marrow disease?

Bone marrow

  • Fatigue.
  • Shortness of breath.
  • Rapid or irregular heart rate.
  • Pale skin.
  • Frequent or prolonged infections.
  • Unexplained or easy bruising.
  • Nosebleeds and bleeding gums.
  • Prolonged bleeding from cuts.