What is aliskiren drug used for?

Aliskiren is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries.

When should aliskiren be taken?

Take this medication by mouth as directed by your doctor, usually once daily. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose.

Does aliskiren increase blood pressure?

Firstly, there is some evidence that aspirin lowers blood pressure. However, it’s not in all cases. The important thing to remember is that aspirin does not lower blood pressure on its own. However, its ability to thin out the blood can benefit some people with high blood pressure.

What is the mechanism of action of aliskiren?

Aliskiren is the first and only approved direct renin inhibitor. The mechanism of action of this drug is unique in that it blocks the RAAS by binding to a pocket in renin itself, preventing it from cleaving angiotensinogen to angiotensin I.

Is aliskiren an ACE inhibitor?

Aliskiren is an orally-active, nonpeptidic, direct inhibitor of renin which simultaneously reduces angiotensin I, angiotensin II and plasma renin activity (PRA). This is the main point of action of aliskiren, making it completely different from ACE inhibitors and ARBs.

Can aliskiren cause hyperkalemia?

Medications that can raise potassium levels – aliskiren may raise potassium levels and cause hyperkalemia. When taken with other potassium-raising medications, the risk is increased.

What is the fastest way to lower systolic blood pressure?

Here are 10 lifestyle changes you can make to lower your blood pressure and keep it down.

  1. Lose extra pounds and watch your waistline.
  2. Exercise regularly.
  3. Eat a healthy diet.
  4. Reduce sodium in your diet.
  5. Limit the amount of alcohol you drink.
  6. Quit smoking.
  7. Cut back on caffeine.
  8. Reduce your stress.

Does aliskiren increase renin?

The Figure (top) shows that the aliskiren:renin ratio increases with each subsequent aliskiren dose up to 300 mg, reaching ratios of ≈20 000 after 5 hours and 1500 to 3000 after 24 hours. At higher doses, the ratio no longer increases, indicating that the rise in renin now matches the rise in aliskiren.

Is aliskiren a diuretic?

Aliskiren works by relaxing blood vessels so blood can flow more easily. It belongs to a class of drugs known as direct renin inhibitors. Hydrochlorothiazide causes your body to get rid of extra salt and water by making more urine. It is called a “water pill” or diuretic.

How does aliskiren reduce blood pressure?

Lowering blood pressure will reduce the risk of strokes and heart attacks. Aliskiren is a renin inhibitor. It works by blocking an enzyme in the body that is necessary to produce a substance that causes blood vessels to tighten. As a result, the blood vessels relax and this decreases the blood pressure.

What are the side effects of aliskiren?

Aliskiren may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • diarrhea.
  • stomach pain.
  • heartburn.
  • cough.
  • rash.
  • dizziness.
  • headache.
  • back pain.