What is a warty Dyskeratoma?

Warty dyskeratoma (WD) is a benign epidermal proliferation first reported in 1957 because of its distinctive histologic findings. WD presents as an umbilicated papule with a keratotic plug, usually limited to the head, neck, or face.

What causes warty dyskeratoma?

Pathophysiology. The etiology of warty dyskeratoma is unclear. It has been classified as a follicular adnexal neoplasm. There is a report of absence of SERCA2 staining by immunohistochemistry, the protein product of ATP2A2, that suggests that warty dyskeratoma may represent an acquired genetic mutation of ATP2A2.

What is acantholytic dyskeratoma?

Acantholytic dyskeratotic acanthoma (ADA) is a rare benign condition characterized by circumscribed epidermal proliferation displaying both acantholysis and dyskeratosis. Most cases are clinically diagnosed as basal cell carcinoma, which leads to their excision and histopathologic examination.

What causes Darier’s disease?

The linear form of Darier disease is caused by ATP2A2 gene mutations that are acquired during a person’s lifetime and are present only in certain cells. These changes are called somatic mutations and are not inherited.

What are Corps Ronds?

Corps ronds refer to cells with small pyknotic nuclei, a perinuclear clear halo and eosinophilic cytoplasm (Figures 4 and 5). Grains are compressed cells with elongated nuclei seen in the stratum corneum and granular layer (Figures 4 and 5).

What is Darier disease?

Darier disease, also known as Darier-White disease, keratosis follicularis, or dyskeratosis follicularis (MIM #124200), is a rare autosomal dominant genodermatosis characterized by a persistent eruption of red-brown, keratotic papules scattered to confluent in a seborrheic distribution, nail abnormalities, pitting of …

What are acantholytic cells?

Acantholysis means loss of coherence between epidermal cells due to the breakdown of intercellular bridges. It is an important pathogenetic mechanism underlying various bullous disorders, particularly the pemphigus group, as well as many non-blistering disorders.

What is Dariers?

Darier disease is a skin condition characterized by wart-like blemishes on the body. The blemishes are usually yellowish in color, hard to the touch, mildly greasy, and can emit a strong odor. The most common sites for blemishes are the scalp, forehead, upper arms, chest, back, knees, elbows, and behind the ear.

Is keratosis genetic?

Keratosis follicularis is a genetic disorder that occurs randomly as the result of a spontaneous genetic change (i.e., new mutation) or the mutation is inherited as an autosomal dominant trait.

What is Grovers disease?

Grover’s disease is a rare, transient skin disorder that consists of small, firm, raised red lesions, most often on the skin of the chest and back. Diagnosis of this disorder becomes apparent under microscopic examination when the loss of the “cement” that holds the skin cells together is observed.

How does Darier’s disease work?

What is the pathophysiology of Warty dyskeratoma?

The etiology of warty dyskeratoma is unclear. It has been classified as a follicular adnexal neoplasm. There is a report of absence of SERCA2 staining by immunohistochemistry, the protein product of ATP2A2, that suggests that warty dyskeratoma may represent an acquired genetic mutation of ATP2A2.

What is the difference between Warty dyskeratoma and Darier’s disease?

Darier’s disease and Grover’s disease differ most significantly clinically from warty dyskeratoma in that warty dyskeratoma is most often a solitary lesion and Darier’s diease and Grover’s disease are not.

What is the histologic pattern of acantholytic dyskeratosis?

As the histologic pattern is an epidermal reaction pattern of acantholytic dyskeratosis, the differential diagnosis often includes Grover’s disease, Darier’s disease, and acantholytic actinic keratosis or squamous cell carcinoma. Therefore, clinicopathologic correlation is necessary.