What is a solitary fibrous tumor?
Solitary fibrous tumors are rare growths of soft tissue cells that can form nearly anywhere in the body. Solitary fibrous tumors most often occur in the lining around the outside of the lungs (pleural solitary fibrous tumors).
How rare is a solitary fibrous tumor?
Solitary fibrous tumor (SFT) is a rare soft tissue neoplasm, with an incidence of about 0,2/100.000/years. It was called “haemangiopericytoma” by Stout and Murray in 1942.
What is a solitary fibrous sarcoma?
Abstract. Solitary fibrous tumor (SFT) is a rare soft tissue sarcoma subtype which mainly affects adults in the fifth and sixth decades of life. Originally part of a spectrum of tumors called hemangiopericytomas, classification has been refined such that SFTs now represent a distinct subtype.
Are fibrous tumors cancerous?
These can be either malignant or benign (non-cancerous). Benign fibrous tumors of the pleura are sometimes called solitary fibrous tumors. They make up approximately 78% to 88% of non-mesothelioma tumors of the pleura.
WHO classification solitary fibrous tumors?
SFT is classified as an intermediate (rarely metastasizing) tumor according to World Health Organization Classification of Tumors of Soft tissue and Bone, 5th edition. The management and prognosis of SFT differs from its malignant mimics and correct diagnosis is therefore important.
What causes SFT?
Abstract: A solitary fibrous tumor (SFT) is a rare spindle cell tumor-derived from mesenchymal cells. It may be linked to the fusion of the NAB2-STAT6 gene caused by 12q chromosome rearrangement. It can occur in the connective tissue of any part of the body; however, it is most common in the pleura.
What causes fibrous tumors?
Is a solitary fibrous Tumour a sarcoma?
Solitary fibrous tumour (SFT) is a very rare sarcoma, most frequently occurring in middle-aged patients. SFT can occur in several anatomic sites like meninges, peritoneum, head and neck, extremities, and viscera [1–3].
What is DPS disease?
Doege–Potter syndrome (DPS) is a paraneoplastic syndrome in which hypoglycemia is associated with solitary fibrous tumors. The hypoglycemia is the result of the tumors producing insulin-like growth factor 2.
What is a fibrous nodule?
Abstract. The solitary fibrous nodule is a rare clinical disease that mainly affects the pleura, but has been occasionally described in other anatomical sites. This type of tumors can have malignant components and therefore it is important to differentiate them from other retroperitoneal masses.
What is the medical term for tumor of fibrous tissue?
[fi-bro´mah] (pl. fibromas, fibro´ mata) a tumor composed mainly of fibrous or fully developed connective tissue. Called also fibroid and fibroid tumor.
What does a solitary fibrous tumor look like on MRI?
CONCLUSION. Solitary fibrous tumors tend to be well-defined, ovoid, heterogeneously enhancing lesions. MRI characteristically depicts areas of low signal intensity that correspond to dense collagen. The findings of lesion multiplicity and hypermetabolism on PET images should raise the suspicion of malignancy.
What are solitary fibrous tumours composed of?
Solitary fibrous tumours have variable cellularity but generally are composed of a collagenous matrix with arrays of spindle cells. Areas of necrosis, cystic or myxoid change, calcification, haemorrhage, increased vascularity, atypia, or malignancy may also be seen 7-8.
What is the management of solitary fibrous tumors (SFTS)?
Management consists of excision and imaging follow-up. Choose Top of page ABSTRACT Introduction General Imaging Features Solitary Fibrous Tumors b… Summary << References CITING ARTICLES SFT are most commonly located in the pleura, but can be encountered in many other parts of the body.
What are solitary (localized) fibrous tumors in the pleura?
Solitary (localized) fibrous tumors in the pleura were first described by Klemperer and Rabin in 1931 [ 1 ]. Solitary fibrous tumors (SFT) are uncommon neoplasms of mesenchymal origin that can be benign or malignant. Although SFT most commonly occur in the pleura, numerous extrapleural sites of involvement have been reported.