What does AUC mean in pharmacokinetics?
area under the curve
INTRODUCTION. In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance rate from the body.
How is AUC clearance calculated?
The AUC can then be estimated. Knowing the bioavailability and the dose, the clearance of the drug may be calculated by dividing the dose absorbed by the AUC.
How do you calculate pharmacokinetic parameters?
The calculation of the pharmacokinetic parameters
- y = y0 + (plateau − y0) ⋅ (1 − e−Kx) Specific to equation 6, t is an independent variable, and C t is a dependent variable.
- t1/2 = 0.693/K.
- Vd = Ass/Css = (v/K)/Css
- CL = K ⋅ Vd = v/Css Note that the calculation of V d in equation 9 is based on the steady state.
How do you calculate AUC in Excel?
The formula for calculating the AUC (cell H18) is =SUM(H7:H17). The calculated value of . 889515 shows a pretty good fit….Figure 1 – ROC Table and Curve.
How do you calculate area under a line?
The area under a curve between two points is found out by doing a definite integral between the two points. To find the area under the curve y = f(x) between x = a & x = b, integrate y = f(x) between the limits of a and b. This area can be calculated using integration with given limits.
Can you integrate area under a curve in Excel?
Finding the area under a curve is a central task in calculus. This process is called finding the definite integral. Microsoft Excel does not have native calculus functions, but you can map your data to a trendline. Then, once you know the equation of this trendline, you can find the integral.
What is AUC dosing?
Audio. 796.mp3. A measure of how much drug reaches a person’s bloodstream in a given period of time after a dose is given. The information is useful for determining dosing and for identifying potential drug interactions.