## What does AUC mean in pharmacokinetics?

Table of Contents

area under the curve

INTRODUCTION. In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance rate from the body.

**How is AUC clearance calculated?**

The AUC can then be estimated. Knowing the bioavailability and the dose, the clearance of the drug may be calculated by dividing the dose absorbed by the AUC.

### How do you calculate pharmacokinetic parameters?

The calculation of the pharmacokinetic parameters

- y = y0 + (plateau − y0) ⋅ (1 − e−Kx) Specific to equation 6, t is an independent variable, and C t is a dependent variable.
- t1/2 = 0.693/K.
- Vd = Ass/Css = (v/K)/Css
- CL = K ⋅ Vd = v/Css Note that the calculation of V d in equation 9 is based on the steady state.

**How do you calculate AUC in Excel?**

The formula for calculating the AUC (cell H18) is =SUM(H7:H17). The calculated value of . 889515 shows a pretty good fit….Figure 1 – ROC Table and Curve.

Cell | Meaning | Formula |
---|---|---|

H9 | AUC | =(F9-F10)*G9 |

## How do you calculate area under a line?

The area under a curve between two points is found out by doing a definite integral between the two points. To find the area under the curve y = f(x) between x = a & x = b, integrate y = f(x) between the limits of a and b. This area can be calculated using integration with given limits.

**Can you integrate area under a curve in Excel?**

Finding the area under a curve is a central task in calculus. This process is called finding the definite integral. Microsoft Excel does not have native calculus functions, but you can map your data to a trendline. Then, once you know the equation of this trendline, you can find the integral.

### What is AUC dosing?

Audio. 796.mp3. A measure of how much drug reaches a person’s bloodstream in a given period of time after a dose is given. The information is useful for determining dosing and for identifying potential drug interactions.