What does a mesalazine enema do?

PENTASA Mesalazine Enema is indicated for the treatment of ulcerative colitis affecting the distal colon and rectum. Adults: The recommended dosage is one enema at bedtime.

How long does mesalamine enema take to work?

This medication is taken as a liquid enema to deliver the medicine directly to the lower portion of your colon. The liquid enema is inserted directly into the rectum and should remain in the colon for at least 20-40 minutes. If taken as prescribed, these medications can work as quickly as 2 to 4 weeks.

How effective is mesalamine enema?

They had been treated with 5-aminosalicylic acid enemas (mesalamine) on a long-term basis. After an initial 12-week course of treatment, 87% of the patients had improved by at least one grade of inflammation (improvement), and 54% of these were asymptomatic with normal colonic mucosa (remission).

When should I take mesalamine enema?

You will usually use mesalazine enemas once a day before you go to bed. Use the enema after doing a poo. This is because the medicine works best when your bowels are empty. Wash your hands before and after using the enema.

What does mesalamine do to the body?

Mesalamine is used to treat and prevent flare-ups of mild to moderately active ulcerative colitis (an inflammatory bowel disease). It works inside the bowels to reduce inflammation and other symptoms of the disease. This medicine is available only with your doctor’s prescription.

Can mesalamine cause liver damage?

Most cases of liver injury attributed to mesalamine have been mild-to-moderate in severity and rapidly reversed when the drug is stopped. There have been published instances of severe hypersensitivity reactions to mesalamine, but no typical instances of acute liver failure or vanishing bile duct syndrome.

Is mesalamine hard on the kidneys?

However, if left undetected, more prolonged exposure to the drug can lead to irreversible kidney failure and end-stage kidney disease. No convincing studies demonstrate efficacy of treatment with corticosteroids.

Does mesalamine affect the liver?