What does a high complement CH50 mean?
Increased levels of complement may indicate: Acute-phase immune response. Cancer. Ulcerative colitis. Heart attack (acute myocardial infarction)
What is a normal range for complement total CH50?
Complement Hemolytic Activity, Total (CH50)
|Test Name:||Complement Hemolytic Activity, Total (CH50)|
|Causes for Rejection:||Improperly labeled, incorrect container, contaminated, insufficient quantity, incorrect/delay in transport.|
|Reference Range:||23 – 60 U/mL|
Is CH50 high in lupus?
The CH50 is typically below normal. Up to 25% of patients with SLE, however, may have much more dramatic reductions in C4 levels, typically associated with significantly subnormal C3 levels and CH50. Three subsets of patients make up the majority of these individuals.
What are complement levels in lupus?
Complement level: C3, C4, and CH50 Because lupus autoantibodies give the same signal and activate complement, measurement of complement can be used to monitor lupus. Because they give sufficient information, It usually suffices to measure only two of the complement proteins, called C3 and C4.
What infections cause high CH50?
What does it mean if your Complement, Total (CH50) result is too high? Elevated complement may also be found in acute inflammatory conditions, leukemia, Hodgkin’s Disease, sarcoma, and Behcet’s Disease.
What can cause elevated CH50?
Elevated complement may be found in acute inflammatory conditions, leukemia, Hodgkin’s Disease, sarcoma, and Behcet’s Disease.
What does complement 60 mean?
The complement system is a group of nearly 60 proteins that are in blood plasma or on the surface of some cells. The proteins work with your immune system and play a role to protect the body from infections, and to remove dead cells and foreign material.
What is the purpose of the CH50 assay?
The CH50 is a screening assay for the activation of the classical complement pathway (Fig 1) and it is sensitive to the reduction, absence and/or inactivity of any component of the pathway.
What disease can cause a high complement level?
If your results show higher than normal amounts or increased activity of complement proteins, it may mean you have one of the following conditions: Certain types of cancer, such as leukemia or non-Hodgkin lymphoma. Ulcerative colitis, a condition in which the lining of the large intestine and rectum become inflamed.