Is craniofacial fibrous dysplasia a tumor?

Fibrous dysplasia was first described by Lichtenstein in 1938 as a disorder characterized by progressive replacement of normal bone elements by fibrous tissue. It is a bone tumor that, although benign, has the potential to cause significant cosmetic and functional disturbance, particularly in the craniofacial skeleton.

How rare is polyostotic fibrous dysplasia?

Fibrous dysplasia (FD) is an uncommon disorder of the skeleton that is rarely cancerous (less than 1 percent). This disorder results in fibrous bone-like tissue that replaces normal, healthy bone, causing the affected areas to be more susceptible to fractures (broken bone).

Can fibrous dysplasia affect the brain?

Threat to neurological function. Whilst this is rare, it can occur if the fibrous dysplasia involves the skull base and in particular may cause narrowing of the apertures in the skull base through which various nerves run.

Does fibrous dysplasia cause headaches?

Fibrous dysplasia originating from the ethmoid bone is a rare disease entity, but may cause severe headache that can be misdiagnosed as “menstrual migraine” because of similar symptoms in female patients.

What causes craniofacial fibrous dysplasia?

Causes. While the exact cause of fibrous dysplasia is unknown, recent studies point to a mutation of Gs alpha protein during prenatal development as a contributing factor. Fibrous dysplasia is not hereditary, meaning parents do not pass the condition to their children.

How long can you live with fibrodysplasia?

The median estimated lifespan of individuals with FOP is approximately 56 years of age.

Does fibrous dysplasia affect life expectancy?

Fibrous dysplasia is a rare bone disorder, commonly associated with pain, deformity and fractures, which may significantly impact on quality of life.

Is fibrous dysplasia an Expansile?

Fibrous dysplasia (FD) is a non-neoplastic tumor-like congenital process, manifested as a localized defect in osteoblastic differentiation and maturation, with the replacement of normal bone with large fibrous stroma and islands of immature woven bone.