How can meperidine cause serotonin syndrome?

How can meperidine cause serotonin syndrome?

Meperidine is one of the most commonly used opioids to relieve acute pain. Through blocking presynaptic serotonin reuptake, meperidine may induce or interact with other serotonergic agents and result in serotonin hyperstimulation.

What is the effect of meperidine DEMEROL to the fetus?

Prolonged use of DEMEROL Tablets or Oral Solution during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts.

Does meperidine cause delirium?

Meperidine was also associated with an increased risk of delirium compared with other opioids, whereas tramadol was not. The risk of delirium appeared to be lower with hydromorphone or fentanyl, compared with other opioids.

Is meperidine a sedative?

Behavioral ratings found meperidine to be an effective sedative, with 0.50 mg/lb and 1.00 mg/lb being significantly more effective than placebo (P < 0.05, Kruskal-Wallis).

Can meperidine be given during labor?

Meperidine is used to relieve pain, particularly during childbirth. It is usually given by injection and provides pain relief for up to four hours. The most common side-effects are feeling dizzy or sleepy, sweating and nausea.

What does stadol do during labor?

Intravenous (IV) Medication- Stadol is a medication which is often used during labor. It is an analgesic which helps to lessen contraction pains. Stadol does not cause numbness or loss of muscle control, but it will change your perception of the intensity of pain during labor. Stadol is injected into your IV.

What is opioid induced delirium?

Opioid-induced neurotoxicity is a multifactorial syndrome that causes a spectrum of symptoms, from mild confusion or drowsiness to hallucinations, delirium, and seizures.

What is meperidine use?

Meperidine is used to relieve pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated. It belongs to the group of medicines called narcotic analgesics (pain medicines). Meperidine acts on the central nervous system (CNS) to relieve pain.

Is Demerol moderate sedation?

Such is the case with meperidine (Demerol). Meperidine is a synthetic opioid that is commonly used in combination with midazolam, a benzodiazepine, to provide moderate sedation for patients undergoing upper endoscopy and colonoscopy (Cohen et al., 2006).