Tuberculosis or TB is a disease which generally affects the lungs of people and is infectious. Reports state that tuberculosis is the second biggest killer worldwide when compared with other diseases which are caused by a single infectious agent.
The researchers, however, have found a substance which could be the answer to fighting off the infection, according to reports. A researchers’ team has discovered the substance which can interfere with the mycomembrane formation of the bacterium which causes the particular disease.
Reports state that the substance has been effective even when used in low concentrations. The study stated that when it is combined with other know antibiotics, then its effectiveness is improved almost 100 times.
The health industry is increasingly facing challenges posed by drug-resistant bacterias or popularly known as superbugs which are resistant to most of the antibiotics generally used by physicians to fight of infections and diseases. However, the pathogen also makes the life of doctors more difficult as its dense mycomembrane hampers the effect of many medications.
Now, the researchers have found a substance which can unsettle the formation of this particular membrane to a significant extent. The team hypothesises that similarly structured beta lactones could “mask” themselves as mycolic acid to enter the mycolic acid metabolic pathways and then block the decisive enzymes.
The researchers hit the bulls-eye with the beta lactone EZ120 and found that it does indeed inhibit the biosynthesis of the mycomembrane and kills mycobacteria effectively.EZ120 is effective even in low doses, easily passes the mycomembrane and exhibits only low toxicity to human cells.
The combined application of this substance with known antibiotics showed a synergistic effect leading to significantly increased effectiveness.”Vancomycin, a common antibiotic, and EZ120 work together very well. When used together, the dose can be reduced over 100-fold.
The findings of the study were published in the journal Angewandte Chemie International Edition.